The promises of precision medicine are often heralded in the medical and lay literature, but routine integration of genomics in clinical practice is still limited. While the “last mile” infrastructure to bring genomics to the bedside has been demonstrated in some healthcare settings, a number of challenges remain — both in the receptivity of today's health system and in its technical and educational readiness to respond to this evolution in care. To improve the impact of genomics on health and disease (...) management, we will need to integrate both new knowledge and new care processes into existing workflows. This change will be onerous and time-consuming, but hopefully valuable to the provision of high quality, economically feasible care worldwide. (shrink)

In addition to treatments of questions of methodology and implications for life and practice, the Handbook includes sections devoted to the major scientific ...

Der emanzipatorische Ansatz des Denkens von Mably und Rousseau und ihre Zuneigung zum «Volk» können sich nicht konsequent zu einem geschlossenen politischen System entfalten, weil die vorindustrielle Sozialperspektive der Autoren und ihre ambivalente Haltung zu den noch traditionellen Unterschichten dem entgegenstehen. Folgerichtig gewinnen ihre politischen Theorien eine verwirrende Vielgestaltigkeit, die immer wieder zu einseitigen Interpretationen geführt hat.

A vast and interesting family of natural semantics for belief revision is defined. Suppose one is given a distance d between any two models. One may then define the revision of a theory K by a formula α as the theory defined by the set of all those models of α that are closest, by d, to the set of models of K. This family is characterized by a set of rationality postulates that extends the AGM postulates. The new postulates (...) describe properties of iterated revisions. (shrink)

Ultimately we will only understand biological agency when we have developed a theory of the organization of biological processes, and science is still a long way from attaining that goal. It may be possible nonetheless to develop a list of necessary conditions for the emergence of minimal biological agency. The authors offer a model of molecular autonomous agents which meets the five minimal physical conditions that are necessary (and, we believe, conjointly sufficient) for applying agential language in biology: autocatalytic reproduction; (...) work cycles; boundaries for reproducing individuals; self-propagating work and constraint construction; and choice and action that have evolved to respond to food or poison. When combined with the arguments from preadaptation and multiple realizability, the existence of these agents is sufficient to establish ontological emergence as against what one might call Weinbergian reductionism. Minimal biological agents are emphatically not conscious agents, and accepting their existence does not commit one to any robust theory of human agency. Nor is there anything mystical, dualistic, or non-empirical about the emergence of agency in the biosphere. Hence the emergence of molecular autonomous agents, and indeed ontological emergence in general, is not a negation of or limitation on careful biological study but simply one of its implications. (shrink)

_Practical Bioethics_ offers a mix of theory and readings, presented in a format that is succinct and approachable. Each chapter begins and ends with a case study, illustrating the core issues at play and emphasizing the practical nature of the dilemmas arising in medicine. Primary source texts are provided to flesh out the issues, and each of these is carefully edited and presented with interwoven explanatory comments to assist student readers. Throughout, J.K. Miles shows the importance of health-care ethics (...) to us all, whether we be medical providers, patients, or both. (shrink)

A vast and interesting family of natural semantics for belief revision is defined. Suppose one is given a distance d between any two models. One may then define the revision of a theory K by a formula $\alpha$ as the theory defined by the set of all those models of $\alpha$ that are closest, by d, to the set of models of K. This family is characterized by a set of rationality postulates that extends the AGM postulates. The new postulates (...) describe properties of iterated revisions. (shrink)

The internalism-externalism debate is one of the oldest debates in epistemology. Internalists assert that the justification of our beliefs can only depend on facts internal to us, while externalists insist that justification can depend on additional, for example environmental, factors. Clayton Littlejohn proposes and defends a new strategy for resolving this debate. Focussing on the connections between practical and theoretical reason, he explores the question of whether the priority of the good to the right might be used to defend (...) an epistemological version of consequentialism, and proceeds to formulate a new 'deontological externalist' view. On this view, the justificatory status of a belief depends upon whether it is fit for the purposes of practical reasoning. Only beliefs that meet externalist standards are fit for such a purpose. If we want to understand how a wide range of norms (e.g., moral norms) apply to rational agents regardless of what their evidence or outlook is like, we have to embrace an externalist account of the justification. (shrink)

In the twentieth century, the social scientific study of religion was dominated by debates surrounding secularization. Yet throughout its reign, secularization theory was subject to a series of theoretical and empirical challenges. Pronouncements of a forthcoming revolution in theory were frequent, yet secularization theory remained largely undisturbed. However, recent years have seen secularization theory decreased in status. Some have located its heir in the post-secular, yet the concept has invited fractious debate. This article surveys a range of engagements with the (...) post-secular, seeking to identify convergences that sit beneath an otherwise divided field. While this survey reveals the failure of the post-secular to fully supplant secularization theory, it does find that central debates in the field today have departed significantly from earlier generations of scholarship, particularly in a reflexivity toward the field’s basic concepts, a skepticism of teleological theories of history, and a renewed focus on the relationship between religion and politics. (shrink)

The central thesis of robust virtue epistemology (RVE) is that the difference between knowledge and mere true belief is that knowledge involves success that is attributable to a subject's abilities. An influential objection to this approach is that RVE delivers the wrong verdicts in cases of environmental luck. Critics of RVE argue that the view needs to be supplemented with modal anti-luck condition. This particular criticism rests on a number of mistakes about the nature of ability that I shall try (...) to rectify here. (shrink)

This paper looks at whether it is possible to unify the requirements of rationality with the demands of normative reasons. It might seem impossible to do because one depends upon the agent’s perspective and the other upon features of the situation. Enter Reasons Perspectivism. Reasons perspectivists think they can show that rationality does consist in responding correctly to reasons by placing epistemic constraints on these reasons. They think that if normative reasons are subject to the right epistemic constraints, rational requirements (...) will correspond to the demands generated by normative reasons. While this proposal is prima facie plausible, it cannot ultimately unify reasons and rationality. There is no epistemic constraint that can do what reasons perspectivists would need it to do. Some constraints are too strict. The rest are too slack. This points to a general problem with the reasons-first program. Once we recognize that the agent’s epistemic position helps determine what she should do, we have to reject the idea that the features of the agent’s situation can help determine what we should do. Either rationality crowds out reasons and their demands or the reasons will make unreasonable demands. (shrink)

This short work examines what the Hippocratic Oath said to Greek physicians 2400 years ago and reflects on its relevance to medical ethics today. Drawing on the writings of ancient physicians, Greek playwrights, and modern scholars, each chapter explores one passage of the Oath and concludes with a modern case discussion. This book is for anyone who loves medicine and is concerned about the ethics and history of the profession.

After briefly outlining the fine-tuning argument (FTA), I explain how it relies crucially on the claim that it is not improbable that God would design a fine-tuned universe. Against this premise stands the divine psychology objection: the contention that the probability that God would design a fine-tuned universe is inscrutable. I explore three strategies for meeting this objection: (i) denying that the FTA requires any claims about divine psychology in the first place, (ii) defining the motivation and intention to design (...) a fine-tuned universe into the theistic hypothesis, and (iii) providing arguments that the relevant probability is not terribly low. While I reject the first two, I conclude, in line with the third, that considerations about life's objective value establish that it is not absurdly improbable that God would design a fine-tuned universe, whether one regards the FTA as an inference merely to a cosmic designer, or to theism proper. Accordingly, the divine psychology objection fails. (shrink)

According to the phenomenal conservatives, beliefs are justified by non-doxastic states we might speak of as ‘appearances’ or ‘seemings’. Those who defend the view say that there is something self-defeating about believing that phenomenal conservatism is mistaken. They also claim that the view captures an important internalist insight about justification. I shall argue that phenomenal conservatism is indefensible. The considerations that seem to support the view commit the phenomenal conservatives to condoning morally abhorrent behavior. They can deny that their view (...) forces them to condone morally abhorrent behavior, but then they undercut the defenses of their own view. (shrink)

Research on interdisciplinary science has for the most part concentrated on the institutional obstacles that discourage or hamper interdisciplinary work, with the expectation that interdisciplinary interaction can be improved through institutional reform strategies such as through reform of peer review systems. However institutional obstacles are not the only ones that confront interdisciplinary work. The design of policy strategies would benefit from more detailed investigation into the particular cognitive constraints, including the methodological and conceptual barriers, which also confront attempts to work (...) across disciplinary boundaries. Lessons from cognitive science and anthropological studies of labs in sociology of science suggest that scientific practices may be very domain specific, where domain specificity is an essential aspect of science that enables researchers to solve complex problems in a cognitively manageable way. The limit or extent of domain specificity in scientific practice, and how it constrains interdisciplinary research, is not yet fully understood, which attests to an important role for philosophers of science in the study of interdisciplinary science. This paper draws upon two cases of interdisciplinary collaboration; those between ecologists and economists, and those between molecular biologists and systems biologists, to illustrate some of the cognitive barriers which have contributed to failures and difficulties of interactions between these fields. Each exemplify some aspect of domain specificity in scientific practice and show how such specificity may constrain interdisciplinary work. (shrink)

Ever since 1942, when Carl Hempel declared that historical events are explained by subsuming them under laws governing the occurrence of similar events, philosophers have debated the validity of explanations based on "covering laws." In _The Logic of Historical Explanation_, Clayton Roberts provides a key to understanding the role of covering laws in historical explanation. He does so by distinguishing between their use at the macro- and micro- levels, a distinction that no other scholar has made. Roberts contends that (...) the positivists were right to believe that covering laws are indispensable in historical explanations but wrong to think that these laws apply to macro-events. Similarly, the humanists were right to declare that historians do not explain the occurrence of macro-events by subsuming them under covering laws but wrong to deny the role of covering laws in tracing the course of events leading to the macro-event. Roberts resolves this debate by showing that, though useless in explaining macro-events, covering laws are indispensable in connecting the steps in an explanatory narrative. He then sets forth the logic of an explanatory narrative, explores the nature of rational explanation, and distinguishes the logic of historical interpretation from the logic of historical explanation. (shrink)

According to Williamson, your evidence consists of all and only what you know (E = K). According to his critics, it doesn’t. While E = K calls for revision, the revisions it calls for are minor. E = K gets this much right. Only true propositions can constitute evidence and anything you know non-inferentially is part of your evidence. In this paper, I defend these two theses about evidence and its possession from Williamson’s critics who think we should break more (...) radically from E = K. (shrink)

Although Weber's path-breaking work on the Protestant Ethic and the Spirit of Capitalism has received much attention ever since it first appeared in 1904-5, recent research has uncovered important new aspects. This volume, the result of an international, interdisciplinary effort, throws new light on the intellectual and cultural background of Weber's work, debates recent criticism of Weber's thesis, and confronts new historical insight on the seventeenth century with Weber's interpretation. Revisiting Weber's thesis serves to deepen our understanding of Weber as (...) much as it will stimulate further research. (shrink)

Conditionalists say that the value something has as an end—its final value—may be conditional on its extrinsic features. They support this claim by appealing to examples: Kagan points to Abraham Lincoln’s pen, Rabinowicz and Rønnow-Rasmussen to Lady Diana’s dress, and Korsgaard to a mink coat. They contend that these things may have final value in virtue of their historical or societal roles. These three examples have become familiar: many now merely mention them to establish the conditionalist position. But the widespread (...) faith in such cases is, I believe, unjustified. This is because, surprisingly, the pen, the dress, and the coat cannot have final value. I argue that the problem is internal: these cases are ruled out by every conditionalist account of final value. Further, the problem with these well-known cases applies to most other supposed examples of extrinsic, final goods. Thus nearly all cases given to support the conditionalist view cannot succeed. I suggest a kind of diagnosis: I claim that these examples are best seen as instances of sentimental value, rather than final value. I close by providing a brief account of sentimental value and explain how it relates to instrumental, intrinsic, and final goodness. (shrink)

According to ‘ought’ implies ‘can’ (OIC), your obligation can never be to do what you cannot do. In a recent attack on OIC, Graham has argued that intuitions about justified intervention can help us determine whether the agent whose actions we use force to prevent would have acted permissibly or not. These intuitions, he suggests, cause trouble for the idea that you can be obligated to refrain from doing what you can refrain from doing. I offer a defense of OIC (...) and explain how non-consequentialists can accommodate his intuitions about his cases. (shrink)

There are many different oughts. There is a moral ought, a prudential ought, an epistemic ought, the legal ought, the ought of etiquette, and so on. These oughts can prescribe incompatible actions. What I morally ought to do may be different from what I self-interestedly ought to do. Philosophers have claimed that these conflicts are resolved by an authoritative ought, or by facts about what one ought to do simpliciter or all-things-considered. However, the only coherent notion of an ought simpliciter (...) has preposterous first-order normative commitments. It is more reasonable to reject the ought simpliciter in favor of the form of normative pluralism advocated in (Tiffany 2007). (shrink)

In this paper, I present a puzzle about epistemic rationality. It seems plausible that it should be rational to believe a proposition if you have sufficient evidential support for it. It seems plausible that it rationality requires you to conform to the categorical requirements of rationality. It also seems plausible that our first-order attitudes ought to mesh with our higher-order attitudes. It seems unfortunate that we cannot accept all three claims about rationality. I will present three ways of trying to (...) resolve this tension and argue that the best way to do this is to reject the idea that strong evidential support is the stuff rationality is made of. In the course of doing this, I shall argue that there is a special class of propositions about the requirements of rationality that we cannot make rational mistakes about and explain how this can be. (shrink)

In the 1960s, the strict opposition between the religious and the secular began to break down, blurring the distinction between political philosophy and political theology. This collapse contributed to the decline of modern liberalism, which supported a neutral, value-free space for capitalism. It also deeply unsettled political, religious, and philosophical realms, forced to confront the conceptual stakes of a return to religion. Gamely intervening in a contest that defies simple resolutions, Clayton Crockett conceives of the postmodern convergence of the (...) secular and the religious as a basis for emancipatory political thought. Engaging themes of sovereignty, democracy, potentiality, law, and event from a religious and political point of view, Crockett articulates a theological vision that responds to our contemporary world and its theo-political realities. Specifically, he claims we should think about God and the state in terms of potentiality rather than sovereign power. Deploying new concepts, such as Slavoj Žižek's idea of parallax and Catherine Malabou's notion of plasticity, his argument engages with debates over the nature and status of religion, ideology, and messianism. Tangling with the work of Derrida, Deleuze, Spinoza, Antonio Negri, Giorgio Agamben, Alain Badiou, John D. Caputo, and Catherine Keller, Crockett concludes with a reconsideration of democracy as a form of political thought and religious practice, underscoring its ties to modern liberal capitalism while also envisioning a more authentic democracy unconstrained by those ties. (shrink)

There is much to like about the idea that justification should be understood in terms of normality or normic support (Smith 2016, Goodman and Salow 2018). The view does a nice job explaining why we should think that lottery beliefs differ in justificatory status from mundane perceptual or testimonial beliefs. And it seems to do that in a way that is friendly to a broadly internalist approach to justification. In spite of its attractions, we think that the normic support view (...) faces two serious challenges. The first is that it delivers the wrong result in preface cases. These cases suggest that the view is either too sceptical or too externalist. The second is that the view struggles with certain kinds of Moorean absurdities. It turns out that these problems can easily be avoided. If we think of normality as a condition on *knowledge*, we can characterise justification in terms of its connection to knowledge and thereby avoid the difficulties discussed here. The resulting view does an equally good job explaining why we should think that our perceptual and testimonial beliefs are justified when lottery beliefs cannot be. Thus, it seems that little could be lost and much could be gained by revising the proposal and adopting a view on which it is knowledge, not justification, that depends directly upon normality. (shrink)

Belief does aim at the truth. When our beliefs do not fit the facts, they cannot do what they are supposed to do, because they cannot provide us with reasons. We cannot plausibly deny that a truth norm is among the norms that govern belief. What we should not say is that the truth norm is the fundamental epistemic norm. In this paper, I shall argue that knowledge is the norm of belief and that the truth norm has a derivative (...) status. Only a knowledge‐first approach to epistemic normativity can explain why epistemic assessment has its inward‐looking focus. (shrink)

The typical epistemology course begins with a discussion of the distinction between justification and knowledge and ends without any discussion of the distinction between justification and excuse. This is unfortunate. If we had a better understanding of the justification-excuse distinction, we would have a better understanding of the intuitions that shape the internalism-externalism debate. My aims in this paper are these. First, I will explain how the kinds of excuses that should interest epistemologists exculpate. Second, I will explain why the (...) intuitions that underwrite the new evil demon argument don't provide support for the internalist claim that justification is just in the head. The positive response that Cohen's example elicits is an indication that the subject should be excused if she violates an epistemic norm, not an indication that no norm has been violated. For just about any conceivable norm we can think of we can imagine situations in which someone violates that norm because they're moved by evidence that misleadingly suggests that they'd conform to it. When that happens, we'll respond positively in just the way we do when we consider Cohen's deceived subjects. When that happens, we cannot say that the subjects' responses were justified because we've stipulated that the subjects' responses contravene the relevant norms. Regardless of whether you think of norms along internalist or externalist lines, you should see that the intuitions that underwrite the new evil demon objection tell us nothing at all about whether a subject conforms to a norm. They tell us nothing about justification. (shrink)

In this paper we take a close look at current interdisciplinary modeling practices in the environmental sciences, and suggest that closer attention needs to be paid to the nature of scientific practices when investigating and planning interdisciplinarity. While interdisciplinarity is often portrayed as a medium of novel and transformative methodological work, current modeling strategies in the environmental sciences are conservative, avoiding methodological conflict, while confining interdisciplinary interactions to a relatively small set of pre-existing modeling frameworks and strategies (a process we (...) call crystallization). We argue that such practices can be rationalized as responses in part to cognitive constraints which restrict interdisciplinary work. We identify four salient integrative modeling strategies in environmental sciences, and argue that this crystallization, while contradicting somewhat the novel goals many have for interdisciplinarity, makes sense when considered in the light of common disciplinary practices and cognitive constraints. These results provide cause to rethink in more concrete methodological terms what interdisciplinarity amounts to, and what kinds of interdisciplinarity are obtainable in the environmental sciences and elsewhere. (shrink)

Abstractionists claim that the only bearers of intrinsic value are abstract, necessarily existing states of affairs. I argue that abstractionism cannot succeed. Though we can model concrete goods such as lives, projects, and outcomes with abstract states, conflating models of goods with the goods themselves has surprising and unattractive consequences. I suggest that concrete states of affairs or facts are the only bearers of intrinsic value. I show how this proposal can overcome the concerns lodged against abstractionism and, in the (...) process, reconnect us with the good. (shrink)

This is part of an authors meets critics session on Daniel Star's wonderful book, Knowing Better. I discuss a potential problem with Kearns and Star's Reasons as Evidence thesis. The issue has to do with the difficulties we face is we treat normative reasons as evidence and impose no possession conditions on evidence. On such a view, it's hard to see how practical reasoning could be a non-monotonic process. One way out of the difficulty would be to allow for (potent) (...) unpossessed reasons but insist that all evidence is possessed evidence. This option, I argue, isn't open to proponents of the Reasons as Evidence thesis. Instead, it seems that they'll have to say that all normative reasons are identified with pieces of possessed evidence. This requires the proponents of the Reasons as Evidence thesis to impose epistemic constraints on norms that some of us find objectionable. (shrink)

Integrative systems biology is an emerging field that attempts to integrate computation, applied mathematics, engineering concepts and methods, and biological experimentation in order to model large-scale complex biochemical networks. The field is thus an important contemporary instance of an interdisciplinary approach to solving complex problems. Interdisciplinary science is a recent topic in the philosophy of science. Determining what is philosophically important and distinct about interdisciplinary practices requires detailed accounts of problem-solving practices that attempt to understand how specific practices address the (...) challenges and constraints of interdisciplinary research in different contexts. In this paper we draw from our 5-year empirical ethnographic study of two systems biology labs and their collaborations with experimental biologists to analyze a significant problem-solving approach in ISB, which we call adaptive problem solving. ISB lacks much of the methodological and theoretical resources usually found in disciplines in the natural sciences, such as methodological frameworks that prescribe reliable model-building processes. Researchers in our labs compensate for the lack of these and for the complexity of their problems by using a range of heuristics and experimenting with multiple methods and concepts from the background fields available to them. Using these resources researchers search out good techniques and practices for transforming intractable problems into potentially solvable ones. The relative freedom lab directors grant their researchers to explore methodological options and find good practices that suit their problems is not only a response to the complex interdisciplinary nature of the specific problem, but also provides the field itself with an opportunity to discover more general methodological approaches and develop theories of biological systems. Such developments in turn can help to establish the field as an identifiably distinct and successful approach to understanding biological systems. (shrink)

In this article, we provide a case study examining how integrative systems biologists build simulation models in the absence of a theoretical base. Lacking theoretical starting points, integrative systems biology researchers rely cognitively on the model-building process to disentangle and understand complex biochemical systems. They build simulations from the ground up in a nest-like fashion, by pulling together information and techniques from a variety of possible sources and experimenting with different structures in order to discover a stable, robust result. Finally, (...) we analyze the alternative role and meaning theory has in systems biology expressed as canonical template theories like Biochemical Systems Theory. (shrink)

In Fallibilism: Evidence and Knowledge, Jessica Brown identifies a number of problems for the so-called knowledge view of justification. According to this view, we cannot justifiably believe what we do not know. Most epistemologists reject this view on the grounds that false beliefs can be justified if, say, supported by the evidence or produced by reliable processes. We think this is a mistake and that many epistemologists are classifying beliefs as justified because they have properties that indicate that something should (...) be excused. Brown thinks that previous attempts to make this case have been unsuccessful. While the difficulties Brown points to are genuine, I think they show that attempts to explain a classificatory judgment haven't been successful. Still, I would argue that the classification is correct. We need a better explanation of this classificatory judgment. I will try to clarify the justification-excuse distinction and explain why it's a mistake to insist that beliefs that violate epistemic norms might be justified. Just as it's possible for a rational agent to act without justification in spite of her best intentions, it's possible that a rational thinker who follows the evidence and meets our expectations might nevertheless believe without sufficient justification. If our justified beliefs are supposed to guide us in deciding what to do, we probably should draw on discussions from morality and the law about the justification/excuse distinction to inform our understanding of the epistemic case. (shrink)

Although preservationists sometimes allege a right of wild areas to remain wild, their arguments do not warrant the ascription of such a right. It is hard to see how any argument to this conclusion could be persuasive, for X having a right to Y requires that depriving X of Y injure X, and the only X we have reason to think can be injured is an X which possesses consciousness. On the other hand, rights are problematic creatures, and the individualistic (...) moral view they presuppose does not accord well with the holistic perspective of many preservationists. While it might be possible to develop this perspective into a moral theory that gives wildemess intrinsic value, there seems a greater need for clarifying the policy implications of accepted moral principles. (shrink)

Successful corporate acquisitions require its managers to achieve substantial performance improvements in order to sufficiently cover acquisition premiums, the expected return of debt and equity investors, and the additional resources needed to capture synergies and accelerate growth. Acquirers understand that achieving the performance improvements necessary to cover these costs and create value for investors will most likely require a significant effort from mergers and acquisitions (M&A) management teams. This understanding drives the common and longstanding practice of offering hefty performance incentive (...) packages to key managers, assuming that financial incentives will induce in-role and extra-role behaviors that drive organizational change and growth. The present study debunks the assumptions of this common M&A practice, providing quantitative evidence that shared vision and autonomous motivation are far more effective drivers of managerial performance than financial incentives. (shrink)